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Fig. 2 Dissemination and metastasis of human tumor cells in zebrafish embryos. (A and C) Highly metastatic human MDA MB-231 breast and low metastatic human OVCAR 8 ovarian cancer cells were implanted into 48 h post-fertilization zebrafish embryos. Tumor cell dissemination and metastasis were detected at day 6 post-injection. Arrows indicate primary tumors and arrowheads indicate disseminated tumor foci. (Scale bar, 500 μm.) (B and D) High-resolution micrographs of A and C, respectively to visualize single metastatic tumor cells in the trunk regions. (Scale bar, 100 μm.)
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Full text @ Proc. Natl. Acad. Sci. USA