IMAGE

Fig. 2

ID

ZDB-IMAGE-101105-39

Antibodies

znp-1

Publication

Butler et al., 2010 - Genetic and chemical modulation of spastin-dependent axon outgrowth in zebrafish embryos indicates a role for impaired microtubule dynamics in hereditary spastic paraplegia

All Figures

Figures for Butler et al., 2010

Image

Figure Caption

Fig. 2 A katna1 splice-blocking (katna1e4i4) morpholino inhibits spinal motor axon outgrowth in a p53-independent manner. Embryos were injected with 1.0 pmol CoMO + 1.6 pmol p53MO (A), 0.8 pmol katna1e4i4 + 1.6 pmol p53MO (B) or 1.0 pmol spg4e7i7 + 1.6 pmol p53MO (C), fixed at 28 hpf, and then immunostained with znp-1. Both katna1 and spast splice-blocking morpholinos inhibit spinal motor axon outgrowth in a p53-independent manner (D). CoMO + p53MO (n=25), spg4e7i7 + p53MO (n=35), katna1e4i4 (n=34); statistical significance was determined using ANOVA with Bonferroni’s multiple comparison test. ***P<0.001. Scale bars: 50 μm.

Figure Data

Expression / Labeling details

Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dis. Model. Mech.