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Fig. 4 Contractile muscle properties of G93R mutant fish are intact, but the response to repeated stimulation is significantly altered. (A) Muscles of G93R mutant fish are capable of producing similar maximum twitch force as nTg siblings (n=9 per genotype, P=0.816). (B) When subjected to repeated 4 ms stimuli at 0.2 Hz, the muscles of G93R mutant fish fatigue more slowly than those of nTg siblings. The average of the percentage of maximum force achieved (CSA dimension) is plotted against time and linear regression applied to the data (n=8 per genotype). (C) The slope values of linear regression of the percentage of maximal force achieved versus time in response to repeated stimulation were significantly different. G93R mutant fish are able to maintain significantly larger forces for a longer period of time in comparison to nTg sibling controls (n=8 per genotype, P=0.018).