ZFIN Image: Clifton et al., 2010, Fig. 5

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Figure Caption

Fig. 5 Reduced intestinal lipid absorption in ezetimibe and compound treated zebrafish larvae.

(A?L) Lateral views of 6 day post-fertilization larvae following fixation and staining with oil red o to mark neutral lipid. (A) Unfed wild type larva. (B) Wild type larva fed 1% egg yolk. Arrows point to lipid in vasculature. (C?I) Compound treated larvae (25 μM) fed 1% egg yolk. There is reduced intestinal lipid in the compound treated larvae, with no evidence of lipid in the vasculature. Hepatic lipid accumulation is not detected. Lipid is present in the intestinal lumen of larvae treated with compound 10 and ezetimibe (50 μM; blue asterisk).

Acknowledgments

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