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Fig. 2
bromi Is Epistatic to Ptch1
Spinal neural tubes from E9.5 WT, bromi, Ptch1, and bromi,Ptch1 mutant embryos immunostained for markers of neural fate. In Ptch1 mutants, Shh, FoxA2, and Nkx2.2 were broadly expressed throughout the open neural tubes, and Pax6 expression was absent. The Ptch1 mutant phenotype was strongly suppressed in bromi,Ptch1 double mutants, whose the closed neural tubes were small, yet showed expression patterns similar to bromi single mutants.
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Reprinted from Developmental Cell, 18(2), Ko, H.W., Norman, R.X., Tran, J., Fuller, K.P., Fukuda, M., and Eggenschwiler, J.T., Broad-Minded Links Cell Cycle-Related Kinase to Cilia Assembly and Hedgehog Signal Transduction, 237-247, Copyright (2010) with permission from Elsevier. Full text @ Dev. Cell