ZFIN Image: Lorent et al., 2010, Fig. S4

Image

Figure Caption

Fig. S4 Notch signaling is required for expansion of the intrahepatic biliary ductal network. A-C: Confocal projections through the liver of wild type larvae (70, 92, and 120 hpf) and larvae treated with DAPT from 48-70 hpf (E), 48-92 hpf (F), 31-120 hpf (D), and 48-120 hpf (H), fixed immediately after the treatment, followed by 2F11 immunostainings. A larva treated with DAPT from 48-70 hpf and then fixed at 92 hpf after DAPT withdrawal at 70 hpf is also shown (G). DAPT treatment arrests intrahepatic biliary development (compare A with E; B with F; C with D and H). There is expansion of the ductal network after DAPT withdrawal (compare G with F).

Acknowledgments

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