ZFIN Image: Lorent et al., 2010, Fig. 5

Image

Figure Caption

Fig. 5 Notch signaling is required for canalicular development. Confocal projections (5 μm) through the liver of a 70-hpf larva (A) and two 92-hpf (C, D) larvae treated with DAPT from 48-70 hpf (A); DAPT from 48-92 hpf (C) and DAPT from 48-70 hpf (D). A 70-hpf (B) and 92-hpf wild type larva (E) are also shown. All larvae were immunostained with Mdr (red) and 2F11 (green) antibodies. DAPT treatment arrests canalicular development (red) and biliary development (green). Canalicular development reinitiates with DAPT withdrawal (D). Note that the depth of these confocal projections is too small to detect reinitiation of duct development upon DAPT withdrawal.

Figure Data

Expression / Labeling details

Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dev. Dyn.