ZFIN Image: Sobral et al., 2009, Fig. 1

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Figure Caption

Fig. 1 A Pipeline to Compare Spatiotemporal Gene Expression Profiles across Evolution

(A) Correspondence of developmental stages between Ciona and zebrafish through an intermediate generic chordate. The stages for the generic chordate are the same as the bilaterian stages from [2].

(B) Generic chordate anatomical ontology. All relationships are “part-of” relationships.

(C) General overview of the comparison process. Species-specific annotations were translated to the “General Chordate” ontology. Unified in situ hybridization (ISH) annotations of orthologous genes were then compared by using an expression distance (see Supplemental Experimental Procedures).

Acknowledgments

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