Inhibition of erbB signaling does not restore hemidesmosome formation in pen/lgl2 mutants. pen/lgl2 mutant basal cells are unable to form hemidesmosomes, even after inhibition of ErbB signaling. EM cross section through larval skin 5dpf reveals hemidesmosome formation at the basal membrane in wild types (A, arrows) whereas pen/lgl2 mutants (B) and pen/lgl2 mutants treated with ErbB inhibitor PD168393 (C) lack these structures.
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