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Fig. S5
Rescue with sAPPα. Left column: whole embryo morphology; right column: tail region magnified. Top and second rows: uninjected and control-MO-injected embryos. Third row, APPb-MO-injected embryo with a curly tail. Fourth row, embryo co-injected with APPb-MO and APP695 mRNA with a tail similar to the control-MO embryo, but with a slight curvature, and disorganized tail fin. Fifth row, embryo co-injected with APPb-MO and sAPPα mRNA with a tail similar to control-MO, but again with a slight curvature and tail fin not fully formed.
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Reprinted from Developmental Biology, 335(1), Joshi, P., Liang, J.O., Dimonte, K., Sullivan, J., and Pimplikar, S.W., Amyloid precursor protein is required for convergent-extension movements during Zebrafish development, 1-11, Copyright (2009) with permission from Elsevier. Full text @ Dev. Biol.