ZFIN Image: Joshi et al., 2009, Fig. S1

Image

Figure Caption

Fig. S1 Morphological defects observed at 48 hpf in embryos injected with APP morpholinos. Left panel shows lateral views of embryos with anterior view to the left and posterior to the right. Right panel shows dorsal views. From top to bottom: uninjected (first row) and control-MO-injected (second row) embryos showed an elongated body axis and tail. APPa morpholino alone (APPa-MO) (third row) showed whole embryo morphology very similar to uninjected and control-MO-injected embryos (first and second rows). By contrast, APPb morpholino (APPb-MO) (fourth row) alone showed a drastically shortened body axis and a severe curly tail. APPa and APPb morpholino injected together (APPa + APPb-MO) (bottom row) also showed a drastically reduced body axis and a severe curly tail, similar to APPb-MO alone.

Acknowledgments

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Reprinted from Developmental Biology, 335(1), Joshi, P., Liang, J.O., Dimonte, K., Sullivan, J., and Pimplikar, S.W., Amyloid precursor protein is required for convergent-extension movements during Zebrafish development, 1-11, Copyright (2009) with permission from Elsevier. Full text @ Dev. Biol.