ZFIN Image: Wilkinson et al., 2009, Fig. 1

Image

Figure Caption

Fig. 1 Ectopic Hedgehog Signaling Expands tbx20 Expression into the Ventral DA but Does Not Suppress the Initiation of HSC Gene Expression

(A) Diagram of transverse section illustrating DA polarization in the zebrafish trunk at 24 hpf.

(B–G) Embryos treated with DMSO or PMA from 15S and probed for tbx20 or runx1 at 24 hpf. Dorsal and ventral DA expression (yellow and red arrows) are shown. PMA treatment expands tbx20 expression into the ventral DA ([C] and [E] compared to [B] and [D]), but runx1 is unaffected (F and G). AV, axial vein; DA, dorsal aorta; NC, notochord; NT, neural tube; PMA, purmorphamine; S, somite.

Acknowledgments

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Reprinted from Developmental Cell, 16(6), Wilkinson, R.N., Pouget, C., Gering, M., Russell, A.J., Davies, S.G., Kimelman, D., and Patient, R., Hedgehog and Bmp polarize hematopoietic stem cell emergence in the zebrafish dorsal aorta, 909-916, Copyright (2009) with permission from Elsevier. Full text @ Dev. Cell