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Fig. S12
NICD-mediated elevation of ephB2 is blocked by nos inhibition.
Zebrafish embryos were assessed by in situ hybridization for ephB2 at 36 hpf (n>25/condition).
(A-D) The effect of L-NAME on ephB2 expression in WT and NICD transgenic embryos; L-NAME treatment blocked the notch-mediated increase in ephB2 staining.
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Reprinted from Cell, 137(4), North, T.E., Goessling, W., Peeters, M., Li, P., Ceol, C., Lord, A.M., Weber, G.J., Harris, J., Cutting, C.C., Huang, P., Dzierzak, E., and Zon, L.I., Hematopoietic stem cell development is dependent on blood flow, 736-748, Copyright (2009) with permission from Elsevier. Full text @ Cell