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Fig. S3 Ectopic Bmp signaling is transiently induced by heat shock. Wild-type (left) and transgenic (right) embryos were heat shocked at the 3-somite stage and fixed at the indicated intervals. All were stained for the presence of phosphorylated Smads 1 and 5. In wild type embryos p-Smad is restricted to the tailbud and developing somites. Transgenic embryos show high levels of p-Smad throughout all tissues within 90 min of heat shock activation. This appears to peak approximately 2.5 h after the heat shock ends.
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Reprinted from Developmental Biology, 329(1), Row, R., and Kimelman, D., Bmp inhibition is necessary for post-gastrulation patterning and morphogenesis of the zebrafish tailbud, 55-63, Copyright (2009) with permission from Elsevier. Full text @ Dev. Biol.