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Fig. S4
PGE2-mediated modulation of wnt signaling affects cell death and proliferation
(A – D) Indo treatment enhanced TUNEL+ cells in the AGM in both WT and wnt8 induced embryos; median representatives are shown.
(E – L) Induction of dkk, axin, or dnTCF enhanced apoptosis; dmPGE2 improved this effect only in dkk transgenics.
(M – P) Induction of wnt8 enhanced BrdU incorporation, while indo treatment diminished BrdU in both WT and wnt8 embryos.
(Q – X) Inhibition of wnt signaling by dkk, axin, or dnTCF diminished BrdU incorporation; the effect of dkk could be rescued by dmPGE2.
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Reprinted from Cell, 136(6), Goessling, W., North, T.E., Loewer, S., Lord, A.M., Lee, S., Stoick-Cooper, C.L., Weidinger, G., Puder, M., Daley, G.Q., Moon, R.T., and Zon, L.I., Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration, 1136-1147, Copyright (2009) with permission from Elsevier. Full text @ Cell