ZFIN Image: Navratilova et al., 2009, Fig. 2

Image

Figure Caption

Fig. 2 Lateral views of HCNE-test transgenic zebrafish larvae expressing GFP at 2 days post fertilization. Left column shows transgenic made with zebrafish HCNEs, right column shows transgenes made with the orthologous human sequence. (A–M) Elements depicted in Fig. 1, direct expression of GFP to telencephalon (C, D, L–P), diencephalon (A, B, E, F, L–P), hindbrain (A–P) and spinal cord (A–M). (O, P) Partial sequence of element dr8 and hs8; (R, S) Transgenes using hs8A element but the zebrafish/human atp11c/ATP11C promoters instead of the zebrafish gata2 promoter. Note similarity of pattern, but much weaker activation. Abbreviations: h: hindbrain; Tg: tegmentum; E: epiphysis; FP: floor plate; R: rhombomeres; Dc: diencephalon; tc: telencephalon; ie: inner ear; sc: spinal cord; C: cerebellum.

Acknowledgments

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Reprinted from Developmental Biology, 327(2), Navratilova, P., Fredman, D., Hawkins, T.A., Turner, K., Lenhard, B., and Becker, T.S., Systematic human/zebrafish comparative identification of cis-regulatory activity around vertebrate developmental transcription factor genes, 526-540, Copyright (2009) with permission from Elsevier. Full text @ Dev. Biol.