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Fig. S2 Camptothecin Treatment Blocks Embryo Development and Cell Proliferation
(A and B)The difference in BrdU incorporation in the tail region between a 1% DMSO control embryo (A) and an embryo incubated in 60 μM camptothecin (B).
(C and D) Camptothecin blocks early embryo development. 1% DMSO and 30 μM camptothecin were applied to dechorionated embryos at 3 hpf. The embryos were fixed at 7 hpf. While the control embryos progressed normally to about 60% epiboly, the camptothecin-treated embryos were completely arrested at the blastula stage.
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Full text @ PLoS Biol.