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Fig. S4 sef is a Primordium-Specific Wnt/β-Catenin Target
(A) In 32hpf wt embryos sef is absent in trailing cells in the primordium and in deposited cells (arrow).
(B and C) (B) 32 hpf apcmcr mutants expresses sef ectopically in all lateral line cells (arrow), although global expression appears overtly normal. In Fgf inhibited 38hpf embryos sef is upregulated in trailing cells and is downregulated in other regions of the embryo, such as the pharyngeal arches (white asterisk) (C).
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Reprinted from Developmental Cell, 15(5), Aman, A., and Piotrowski, T., Wnt/beta-catenin and Fgf signaling control collective cell migration by restricting chemokine receptor expression, 749-761, Copyright (2008) with permission from Elsevier. Full text @ Dev. Cell