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Fig. 4 Effects of mesendoderm deficiencies on expression of dlx-3. Shown are expression patterns of dlx-3 at (A–D) 11 h, (E–H) 12 h, and (I–L) 14 h. Otic regions (arrows) express high levels of dlx-3 at all of the time points shown in wild-type (A, E, I) and ntl- (B, F, J) embryos. In contrast, upregulation of dlx-3 in the otic regions is delayed in oep- embryos (C, G, K), which are deficient in prechordal mesoderm. The delay is even greater in ntl-;oep- embryos (D, H, L), which are deficient in virtually all cephalic mesendoderm.
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Reprinted from Developmental Biology, 206, Mendonsa, E.S. and Riley, B.B., Genetic analysis of tissue interactions required for otic placode induction in the zebrafish, 100-112, Copyright (1999) with permission from Elsevier. Full text @ Dev. Biol.