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Fig. 4 Expression of noggin2 during embryogenesis. (A) At the end of gastrulation, nog2 expression starts in the notochord. (B) At the 10-somite stage, nog2 is expressed in the telencephalon (te) and anterior diencephalon (di) as well as the tail bud (arrow). (C) At the 12-somite stage, nog2 transcripts are present in the antero-medial part of the somites. (D) At the 16-somite stage, additional nog2 expression is observed in the dorsal hinbrain at the level of rhombomere 2 and 4 (arrowheads), the dorsal aspect of the caudal spinal cord (open arrowhead), and the mesenchyme lining the tail bud (arrow). (E) At 20 h of development, nog2 expression is restricted to distinct dorsal and ventral aspects of the somite. (F) At 30 h of development, nog2 expression persists in the ventro-medial somite, but is no more detectable dorsally. (G) At 36 h of development, nog2 is expressed in the dorsal hindbrain walls. (H) At 48 h of development nog2 expression in the hindbrain becomes increasingly complex. (I) At 72 h of development, nog2 is expressed in numerous small cell populations in the head. (A, B) Lateral view, dorsal to the right. (C) Dorsal view, anterior to the left. (D) Lateral view, anterior to the left. (E, F) Transversal sections at tail level. (G) Transversal section at the level of the anterior hindbrain. (H) Dorsal view, anterior to the left. (I) Longitudinal optical cross section through the head.
Reprinted from Developmental Biology, 214(1), Fürthauer, M., Thisse, B., and Thisse, C., Three different noggin genes antagonize the activity of bone morphogenetic proteins in the zebrafish embryo, 181-196, Copyright (1999) with permission from Elsevier. Full text @ Dev. Biol.