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Fig. 4 Gene expression in regenerating caudal fins treated with 5 μM solanidine (A, C, E) or cyclopamine (B, D, F). After 1 day of cyclopamine, ptc1 expression, normally expressed in a single domain (A), is absent (B) and shh, normally expressed in two domains (C, E, arrows) is present as a single and expanded domain along the proximal-distal axis (D). By day 3 of treatment, cyclopamine-treated fins show only one weak and diffuse domain of shh expression (F, arrows) in the region of pigment accumulation and lepidotrichia termination (square brackets). (Bar = 150 μm.)
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Full text @ Proc. Natl. Acad. Sci. USA