|
Fig. 2 Expression of ndrg4 during zebrafish nervous system development by whole mount in situ hybridization. (A) ndrg4 was observed for the first time in the CNS at the 10-somite stage. (B) By 21-somites, ndrg4 is expressed in telencephalon, ventral diencephalon and spinal chord. (C–E) similar expression patterns of ndrg4 in CNS and sensory system at 22–27 hpf. Expression of ndrg4 in nervous system is increased at 33 hpf (F), 48 hpf (G) and 72 hpf (I). (H) Transverse section at 48 hpf showing the strong signal in the retina of the eyes with restriction of expression from the retina proliferative zone (rpz). (A, C–E,G) Dorsal views with anterior towards the left; (B, F, H), lateral views. allg, anterior lateral line ganglion; ce, cerebellum; di, diencephalons; pllg, posterior lateral line ganglion; rm, rhombomeres; teg, tegmentum; tel, telencephalon; trg, trigeminal ganglion.
Reprinted from Developmental Biology, 317(2), Qu, X., Jia, H., Garrity, D.M., Tompkins, K., Batts, L., Appel, B., Zhong, T.P., and Baldwin, H.S., ndrg4 is required for normal myocyte proliferation during early cardiac development in zebrafish, 486-496, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.