ADMP and TR-ADMP have opposite effects. wt embryos were injected at the one-cell stage with admp RNA (600 pg) or tr-admp RNA (600 pg) and compared to uninjected siblings (uninj.). (A–I) Flat mounts of stained embryos, anterior to the top. (A–C) Flat mounts of embryos stained at 95% epiboly with hgg1, ntl, her5 probes in red and otx2, myoD probes in dark blue. (D–F) Flat mounts of embryos stained at the 10-somite stage with hgg1, ntl, krox20 probes in red and pax6, her5, gata1 probes in dark blue. (D) her5 (black arrow), gata1 (red arrow), and the posterior limit of pax6 expression domain (arrowhead), are indicated. (G–I) Flat mount of embryos stained at the 10-somite stage with ntl, krox20, her5 probes in red and fkd6 probe in dark blue. (G) her5 domain (black arrow) is indicated. (I) End of the notochord is frequently split in tr-admp-injected embryos (arrow).
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