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Fig. 6 The Cyc (Nodal) signal controls the activity of the netrin1 transgene. (A, B) netrin1 (A) and –1.1netrin1:gfp/FPE (B) expression in the floor plate is absent in cyc mutants (blue arrowhead) while the hypochord expression is normal (black arrowhead, h). (C, D) Cyc misexpression induces ectopic expression (white arrowhead, e) of netrin1 (C) and gfp (D). Orientation of embryos: lateral views of the trunk at 24 hpf, anterior left and dorsal up. Abbreviations: e, ectopic floor plate; f, floor plate; h, hypochord. Scale bar represents 25 μm.
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Reprinted from Developmental Biology, 252(1), Rastegar, S., Albert, S., Le Roux, I., Fischer, N., Blader, P., Müller, F., and Strähle, U., A floor plate enhancer of the zebrafish netrin1 gene requires Cyclops (Nodal) signalling and the winged helix transcription factor FoxA2, 1-14, Copyright (2002) with permission from Elsevier. Full text @ Dev. Biol.