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Fig. S1 Rescue of the lifr MO phenotype by co-injection of the lifr MO with lifr synthetic mRNA. Uninjected embryos exhibited no morphological defects (A) and developed normal cranial ganglia (B) at 48 hpf. In contrast, lifr MO injected embryos exhibited severe hydrocephaly (C) and possess several defects in branchiomotor neuron development (D) at 48 hpf. Co-injection of lifr MO with lifr mRNA rescued the lifr MO phenotype and resulted in ∼92% of embryos displaying a normal morphological phenotype (E), and ∼97% of embryos developing normal branchiomotor neurons (F).
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Reprinted from Developmental Biology, 314(2), Hanington, P.C., Patten, S.A., Reaume, L.M., Waskiewicz, A.J., Belosevic, M., and Ali, D.W., Analysis of leukemia inhibitory factor and leukemia inhibitory factor receptor in embryonic and adult zebrafish (Danio rerio), 250-260, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.