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Fig. S2 Zic1 and Zic4 function is required after 18 hpf for dorsal neural proliferation in the hindbrain. (A–D) Dorsal confocal sections (3 μm thick; longitudinal view) through hindbrain immunolabeled with BrdU, marking cells in the S-phase of the cell cycle, at 18 hpf (A,B) and 24 hpf (C,D) in control (A,C) and Zic1 + 4 morphants (B,D). No change in hindbrain proliferation is detected at 18 hpf in Zic1 + 4 morphants (B, n = 11) compared to control embryos (A, n = 10), whereas at 24 hpf, proliferation is markedly reduced in Zic1 + 4 morphants (D, n = 8) compared to control embryos (C, n = 13).
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Reprinted from Developmental Biology, 314(2), Elsen, G.E., Choi, L.Y., Millen, K.J., Grinblat, Y., and Prince, V.E., Zic1 and Zic4 regulate zebrafish roof plate specification and hindbrain ventricle morphogenesis, 376-392, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.