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Fig. S1

ID: ZDB-IMAGE-071102-6
Publication: Sheets et al., 2007 - Zebrafish Melanophilin Facilitates Melanosome Dispersion by Regulating Dynein
All Figures: Figures for Sheets et al., 2007

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Fig. S1 Characterization of Melanosome Transport in Wild-Type Zebrafish. Melanocyte pigment granules in five-day-old swimming larvae completely aggregate within 5 min of exposure to melanin concentrating hormone (MCH) and completely disperse within 10 min of exposure to α-melanin stimulating hormone (MSH) (shown in [A]). The drug carrier, DMSO, does not affect melanosome distribution (data not shown). We used primary cell cultures of melanocytes from wild-type larvae to confirm that the cAMP signaling pathway that regulates aggregation and dispersion in other species also directs pigment granule movements in zebrafish (shown in [B]; Table 1).

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