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Fig. 4 Int6 and Mek signaling interact in vivo. (A–C). Only embryos treated with the 1.0 μM CI-1040, and not 0.25 μM, show a loss of posterior structures, in contrast to (D) int6 morphants (int6 MO 0.25 ng). (E, F) In combination with 0.25 μM of CI-1040, 0.25 μg of int6 MO causes a dramatic alteration of the anterior-posterior axis.
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