Fig. 1

Fig. 1 Effect of ERRα-targeting MOs on zebrafish epiboly. (A) Side views (dorsal to the right) of embryos injected either with the control MO (upper panels) or with two ERRα-targeting MOs (errMO 1+2; lower panels) at different stages of development (hours post-fertilization {hpf} are indicated, according to the one of the control and wild type embryos). (B) Mean epiboly progression at different times after fertilization of wild type (green line), controlMO- (red line) and errMOs-injected (blue line) embryos. Note that wild type and control MO embryos have already reached the tail bud stage at the last time point (dashed line). Except for this last case, P values of the Student′s t test are indicated when significant (n> = 6). (C) Strength of epiboly delay as evaluated by microscopic observation when the control embryos reached 80% of epiboly. Embryos were scored as unaffected, mildly or strongly delayed. Number of embryos examined for each condition is indicated below the graph.