Fig. 8 Ocular genetic mosaics of bala69 mutant and wild-type cells. (A) 24 hpf genetic mosaic embryos showing a high contribution of lineage-labeled donor cells (red) to ocular structures. (B) 5 dpf whole embryo phenotypes of wild-type donor to wild-type host (top) and bala69-donor to wild-type host ocular chimeras (bottom). Note the irregular pupil in the absence of other body phenotypes in the bala69 to wild-type ocular mosaic. (C) Ocular phenotype of wild-type to wild-type mosaics (top) show no abnormalities, whereas (D, E) bala69 to wild-type ocular mosaics show a spectrum of phenotypes including (D) pinhole pupils and severe microphthalmia and (E) iridophore patterning defects with cataracts.
Reprinted from Developmental Biology, 299(1), Semina, E.V., Bosenko, D.V., Zinkevich, N.C., Soules, K.A., Hyde, D.R., Vihtelic, T.S., Willer, G.B., Gregg, R.G., and Link, B.A., Mutations in laminin alpha 1 result in complex, lens-independent ocular phenotypes in zebrafish, 63-77, Copyright (2006) with permission from Elsevier. Full text @ Dev. Biol.