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Fig. 9 Model describing the role of Notch-ligands in pancreatic cell differentiation. The timeline is on the left and relevant stages of pancreatic differentiation are indicated: beta-cells differentiating at 12-somite and alpha-cell differentiating at 20-somite stage will contribute to the first bud while the second bud, differentiating at 33 hpf, is supposed to form the exocrine tissue and some endocrine cells. The role of each Notch ligand in limiting the number of differentiating precursors is indicated.
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Reprinted from Developmental Biology, 301(1), Zecchin, E., Filippi, A., Biemar, F., Tiso, N., Pauls, S., Ellertsdottir, E., Gnugge, L., Bortolussi, M., Driever, W., and Argenton, F., Distinct delta and jagged genes control sequential segregation of pancreatic cell types from precursor pools in zebrafish, 192-204, Copyright (2007) with permission from Elsevier. Full text @ Dev. Biol.