COX-1 signaling is required at 25 somite stage for posterior vessel formation. We monitored the presence of posterior vessel defect at 38 hpf after starting indomethacin treatment at various stages. Starting treatment at 20 s, 25 s, 25 hr or 30 hpf to 38 hpf all resulted in posterior vessel defect. Starting treatment at 5 s to any stage before 25 somites resulted in absence of posterior vessel defect, whereas ending the treatment at 28 hpf and 32 hpf resulted in posterior vessel defect in 35% and 80% of the embryos respectively. Red line indicates timing of indomethacin treatment.
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