ZFIN Image: Lakowski et al., 2007, Fig. 11

Image

Figure Caption

Fig. 11 A subset of bipolar cells in the adult mouse retina express the zebrafish Pax6a BAC transgene. (A–D) In addition to being expressed in amacrine cells, DsRed is also expressed in a small number of morphologically distinct cells in the bipolar region of the INL, which are specifically imaged in this figure (arrows). These cells also express EGFP (B and D, F and H), Chx10 (C, D), and Prox1 (G, H); Chx10 and Prox1 are both expressed by bipolar cells in the adult retina. However, the majority of Chx10 or Prox1 expressing cells (blue-labeled cells in D and H, respectively) do not express the transgene. (E–H) Prox1-expressing horizontal cells (hc) coexpress EGFP, but not DsRed. (I–L) AII amacrine cells coexpress Prox1, GlyT1, and EGFP (arrowheads). Asterisks denote non-specific staining from the secondary used in this triple-label experiment.

Acknowledgments

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Reprinted from Developmental Biology, 307(2), Lakowski, J., Majumder, A., and Lauderdale, J.D., Mechanisms controlling Pax6 isoform expression in the retina have been conserved between teleosts and mammals, 498-520, Copyright (2007) with permission from Elsevier. Full text @ Dev. Biol.