ZFIN Image: Yeyati et al., 2007, Fig. 1

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Figure Caption

Fig. 1 Developmental Defects Observed among WT Strains after Decreasing Hsp90 Function at 30% Epiboly (A) Frequencies: Embryos were treated at 30% epiboly with 10 μM radicicol (blue) or 3.3 μM 17AAG (orange). Rate of survival is the relative percentage of live embryos at 48 hpf compared to the relevant control siblings. Abnormal heart looping includes heterotaxia and nonlooping of the heart tube; severely oedematous fish with consequently abnormal heart were excluded. (B–O) Examples of observed phenotypes: (B–D) Developmental delay observed at 24 hpf after treatments. Interrupted caudal fin fold (dotted lines) after radicicol (E) or 17AAG (F) treatment. Notochord folds (arrows) after radicicol (G) and 17AAG (H). Drug-induced heart oedema with abnormal heart morphology after radicicol (I) and 17AAG (J). Radicicol-induced mild oedema with abnormal heart looping (K). WT (L) or inverted heart looping after 17AAG (M), radicicol (N), or Hsp90 morpholino injections (O). Black arrows indicate the position of the ventricle.

Acknowledgments

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