ZFIN Image: Nambiar et al., 2004, Fig. 4

Image

Figure Caption

Fig. 4 col mutants display an expansion of non-neural ectoderm and a reduction in neural tissue during late gastrulation. (A,B) At 80% epiboly (8.5 hpf; A; lateral view), gata2 is expressed by non-neural ectoderm in wild-type embryos. The domain of gata2 expression is expanded dorsally and anteriorly in col mutants (B). Arrowheads in A and B denote limits of the gata2 expression domains. (C,D) At 75% epiboly (8 hpf; C; lateral view), otx2 is expressed by the forebrain and midbrain anlage of the neuroectoderm in wild-type embryos (C). In col mutants (D), otx2 expression is reduced and the anterior border of the expression domain (arrowheads) does not reach the animal pole.

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Reprinted from Developmental Biology, 267(1), Nambiar, R.M., and Henion, P.D., Sequential antagonism of early and late Wnt-signaling by zebrafish colgate promotes dorsal and anterior fates, 165-80, Copyright (2004) with permission from Elsevier. Full text @ Dev. Biol.