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Fig. 11 Implantation of Fgf4-soaked beads into ext2/dak and extl3/box embryos. Dorsal (A-C) and lateral (A′- C") views of 2.5-day-old embryos, anterior towards the left. Expression of genes was examined by in situ hybridisation in operated left-hand side (A′- C′) and unoperated right-hand side fin buds (A"-C"). Fgf4 protein beads strongly rescued the expression of eng1a (A-A") and wnt7a (B-B") in ext2/dak mutant embryos. Similarly, shh (C-C") expression was rescued in extl3/box following implantation of Fgf4-soaked beads. Yellow asterisks indicate position of implanted beads (A′- C′). LV, left view of embryo; RV, right view of same embryo.