|
Fig. 9 Summary of retinotectal mutants. The 13 loci are predicted to affect different aspects of tectal development and architecture. The ddl protein is required for differentiation of most RGCs. The vrt, tard and late gene products ensure timely innervation of the tectum. Products of vrt and coma organize the fascicles in the optic tract, while bluk, clew, blin and coma regulate fiber-fiber interaction in the tectum. Proteins encoded by fuzz, beyo and brek confine axons to the neuropil, while drg is required for targeting axons to the SFGS. (The deeper layers of the tectum, SGC and SAC/SPV, are not labeled by Brn3c:mGFP.)