GENOTYPE
umc1Tg
- ID
- ZDB-GENO-140603-1
- Name
- umc1Tg
- Previous Name
- Background
- Unspecified
- Affected Genomic Region
- Current Source
- No data available
Notes
Genotype Composition
| Genomic Feature | Construct | Lab of Origin | Zygosity | Parental Zygosity |
|---|---|---|---|---|
| umc1Tg | Tg(mitfa:Hsa.HRAS_G12V,mitfa:GFP) | Hurlstone Lab | unknown | Unknown |
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Fish utilizing umc1Tg
- Henderson, F., Johnston, H.R., Badrock, A.P., Jones, E.A., Forster, D., Nagaraju, R.T., Evangelou, C., Kamarashev, J., Green, M., Fairclough, M., Barinaga-Rementeria Ramirez, I., He, S., Snaar-Jagalska, B.E., Hollywood, K., Dunn, W.B., Spaink, H.P., Smith, M.P., Lorigan, P., Claude, E., Williams, K.J., McMahon, A.W., Hurlstone, A. (2019) Enhanced fatty acid scavenging and glycerophospholipid metabolism accompanies melanocyte neoplasia progression in zebrafish. Cancer research. 79(9):2136-2151
- Fernandez Del Ama, L., Jones, M., Walker, P., Chapman, A., Braun, J.A., Mohr, J., Hurlstone, A.F. (2016) Reprofiling using a zebrafish melanoma model reveals drugs cooperating with targeted therapeutics. Oncotarget. 7(26):40348-40361
- Herrero, A., Pinto, A., Colón-Bolea, P., Casar, B., Jones, M., Agudo-Ibáñez, L., Vidal, R., Tenbaum, S.P., Nuciforo, P., Valdizán, E.M., Horvath, Z., Orfi, L., Pineda-Lucena, A., Bony, E., Keri, G., Rivas, G., Pazos, A., Gozalbes, R., Palmer, H.G., Hurlstone, A., Crespo, P. (2015) Small Molecule Inhibition of ERK Dimerization Prevents Tumorigenesis by RAS-ERK Pathway Oncogenes. Cancer Cell. 28:170-82
- Dalton, L.E., Kamarashev, J., Ramirez, I.R., White, G., Malliri, A., and Hurlstone, A. (2013) Constitutive Rac Activation is not Sufficient to Initiate Melanocyte Neoplasia but Accelerates Malignant Progression. The Journal of investigative dermatology. 133(6):1572-81
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