Gene
rnf31
- ID
- ZDB-GENE-170316-1
- Name
- ring finger protein 31
- Symbol
- rnf31 Nomenclature History
- Previous Names
-
- hoip (1)
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable linear polyubiquitin binding activity; polyubiquitin modification-dependent protein binding activity; and ubiquitin protein ligase activity. Acts upstream of or within cilium assembly. Predicted to be part of LUBAC complex. Human ortholog(s) of this gene implicated in immunodeficiency 115. Orthologous to human RNF31 (ring finger protein 31).
- Genome Resources
-
- Alliance (1)
- Gene:100334178 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Shen et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 115 | Alliance | Immunodeficiency 115 with autoinflammation | 620632 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000315 | B-box-type zinc finger |
| Domain | IPR001841 | Zinc finger, RING-type |
| Domain | IPR001876 | Zinc finger, RanBP2-type |
| Domain | IPR002867 | IBR domain |
| Domain | IPR018997 | PUB domain |
| Domain | IPR032065 | E3 ubiquitin-protein ligase RNF31, UBA-like domain |
| Domain | IPR041031 | RNF31, C-terminal |
| Domain | IPR044066 | TRIAD supradomain |
| Domain | IPR047539 | E3 ubiquitin-protein ligase RNF31, UBA domain |
| Domain | IPR047540 | E3 ubiquitin-protein ligase RNF31-like, BRcat domain |
| Domain | IPR047541 | E3 ubiquitin-protein ligase RNF31-like, modified RING finger, HC subclass |
| Domain | IPR047542 | E3 ubiquitin-protein ligase RNF31-like, Rcat domain |
| Family | IPR026254 | E3 ubiquitin-protein ligase RNF31-like |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR036339 | PUB-like domain superfamily |
| Homologous_superfamily | IPR036443 | Zinc finger, RanBP2-type superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | B-box-type zinc finger | E3 ubiquitin-protein ligase RNF31-like | E3 ubiquitin-protein ligase RNF31-like, BRcat domain | E3 ubiquitin-protein ligase RNF31-like, modified RING finger, HC subclass | E3 ubiquitin-protein ligase RNF31-like, Rcat domain | E3 ubiquitin-protein ligase RNF31, UBA domain | E3 ubiquitin-protein ligase RNF31, UBA-like domain | IBR domain | PUB domain | PUB-like domain superfamily | RNF31, C-terminal | TRIAD supradomain | Zinc finger, RanBP2-type | Zinc finger, RanBP2-type superfamily | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3B0A7 | InterPro | 1052 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance