Gene

mfrp

ID
ZDB-GENE-160728-150
Name
membrane frizzled-related protein
Symbol
mfrp Nomenclature History
Previous Names
  • si:cabz01033205.3 (1)
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Involved in eye development. Predicted to localize to integral component of membrane. Used to study hyperopia and microphthalmia. Human ortholog(s) of this gene implicated in isolated microphthalmia 5; late-onset retinal degeneration; microphthalmia; nanophthalmos; and retinitis pigmentosa. Is expressed in ciliated epithelial cell and retinal pigmented epithelium. Orthologous to several human genes including C1QTNF5 (C1q and TNF related 5).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Collery et al., 2016
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from Collery et al., 2016
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mfrp Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
isolated microphthalmia 5 Alliance Microphthalmia, isolated 5 611040
nanophthalmos Alliance Nanophthalmos 2 609549
Associated With mfrp Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
Domain IPR000859 CUB domain
Domain IPR020067 Frizzled domain
Homologous_superfamily IPR035914 Spermadhesin, CUB domain superfamily
Homologous_superfamily IPR036055 LDL receptor-like superfamily
Homologous_superfamily IPR036790 Frizzled cysteine-rich domain superfamily
Repeat IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
Domain Details Per Protein
Protein Length CUB domain Frizzled cysteine-rich domain superfamily Frizzled domain LDL receptor-like superfamily Low-density lipoprotein (LDL) receptor class A, conserved site Low-density lipoprotein (LDL) receptor class A repeat Spermadhesin, CUB domain superfamily
UniProtKB:F1QRG7 572
UniProtKB:A0A8M3B0L4 311
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations