ZFIN is now using GRCz12tu for Genomic Data
Gene
mfrp
- ID
- ZDB-GENE-160728-150
- Name
- membrane frizzled-related protein
- Symbol
- mfrp Nomenclature History
- Previous Names
-
- si:cabz01033205.3 (1)
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Is expressed in ciliated epithelial cell and retinal pigmented epithelium. Used to study hyperopia and microphthalmia. Human ortholog(s) of this gene implicated in isolated microphthalmia 5; microphthalmia; nanophthalmos; and retinitis pigmentosa. Orthologous to human MFRP (membrane frizzled-related protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Collery et al., 2016
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Collery et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| isolated microphthalmia 5 | Alliance | Microphthalmia, isolated 5 | 611040 |
| nanophthalmos | Alliance | Nanophthalmos 2 | 609549 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| microphthalmia | mfrpmw78/mw78 | standard conditions | Collery et al., 2016 |
| hyperopia | mfrpmw78/mw78 | standard conditions | Collery et al., 2016 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR023415 | Low-density lipoprotein (LDL) receptor class A, conserved site |
| Domain | IPR000859 | CUB domain |
| Domain | IPR020067 | Frizzled domain |
| Homologous_superfamily | IPR035914 | Spermadhesin, CUB domain superfamily |
| Homologous_superfamily | IPR036055 | LDL receptor-like superfamily |
| Homologous_superfamily | IPR036790 | Frizzled cysteine-rich domain superfamily |
| Repeat | IPR002172 | Low-density lipoprotein (LDL) receptor class A repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | CUB domain | Frizzled cysteine-rich domain superfamily | Frizzled domain | LDL receptor-like superfamily | Low-density lipoprotein (LDL) receptor class A, conserved site | Low-density lipoprotein (LDL) receptor class A repeat | Spermadhesin, CUB domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QRG7 | InterPro | 572 | |||||||
| UniProtKB:A0A8M3B0L4 | InterPro | 311 | |||||||
| UniProtKB:A0AC58HEH2 | InterPro | 432 | |||||||
| UniProtKB:A0AC58HEH8 | InterPro | 311 | |||||||
| UniProtKB:A0AC58HEK5 | InterPro | 572 | |||||||
| UniProtKB:A0ACD6B6A9 | InterPro | 572 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
si:cabz01033205.3-201
(1)
|
Ensembl | 2,389 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers