Gene
tomt
- ID
- ZDB-GENE-160629-1
- Name
- transmembrane O-methyltransferase
- Symbol
- tomt Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable catechol O-methyltransferase activity. Involved in auditory behavior. Acts upstream of or within several processes, including detection of mechanical stimulus involved in sensory perception; neuromast development; and neuron differentiation. Located in Golgi apparatus; basolateral plasma membrane; and endoplasmic reticulum. Is expressed in anterior macula; inner ear; neuromast hair cell; and posterior macula. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 63. Orthologous to human LRTOMT (leucine rich transmembrane and O-methyltransferase domain containing) and TOMT (transmembrane O-methyltransferase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Erickson et al., 2017
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Class I-like SAM-dependent O-methyltransferase | S-adenosyl-L-methionine-dependent methyltransferase superfamily |
|---|---|---|---|---|
| UniProtKB:A0A8M9PLX8 | InterPro | 259 | ||
| UniProtKB:A0A193KX02 | InterPro | 259 | ||
| UniProtKB:A0AB13ABH8 | InterPro | 259 | ||
| UniProtKB:A0AB32T7Z5 | InterPro | 317 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Sun, P., Smith, E., Nicolson, T. (2023) Transmembrane channel-like (Tmc) subunits contribute to frequency sensitivity in the zebrafish utricle. The Journal of neuroscience : the official journal of the Society for Neuroscience. 44(1):
- Kawano, D., Pinter, K., Chlebowski, M., Petralia, R.S., Wang, Y.X., Nechiporuk, A.V., Drerup, C.M. (2022) NudC regulated Lis1 stability is essential for the maintenance of dynamic microtubule ends in axon terminals. iScience. 25:105072105072
- Venuto, A., Smith, C.P., Cameron-Pack, M., Erickson, T. (2022) Alone in a crowd: effect of a nonfunctional lateral line on expression of the social hormone parathyroid hormone 2. Biology Open. 11(10):
- Mandal, A., Wong, H.C., Pinter, K., Mosqueda, N., Beirl, A., Lomash, R.M., Won, S., Kindt, K.S., Drerup, C.M. (2020) Retrograde mitochondrial transport is essential for organelle distribution and health in zebrafish neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 41(7):1371-1392
- Pacentine, I.V., Nicolson, T. (2019) Subunits of the mechano-electrical transduction channel, Tmc1/2b, require Tmie to localize in zebrafish sensory hair cells. PLoS Genetics. 15:e1007635
- Erickson, T., Morgan, C.P., Olt, J., Hardy, K., Busch-Nentwich, E.M., Maeda, R., Clemens-Grisham, R., Krey, J.F., Nechiporuk, A.V., Barr-Gillespie, P.G., Marcotti, W., Nicolson, T. (2017) Integration of Tmc1/2 into the mechanotransduction complex in zebrafish hair cells is regulated by Transmembrane O-methyltransferase (Tomt). eLIFE. 6
- Seiler, C. and Nicolson, T. (1999) Defective calmodulin-dependent rapid apical endocytosis in zebrafish sensory hair cell mutants. Journal of neurobiology. 41(3):424-434
- Nicolson, T., Rüsch, A., Friedrich, R.W., Granato, M., Ruppersberg, J.P., and Nüsslein-Volhard, C. (1998) Genetic analysis of vertebrate sensory hair cell mechanosensation: the zebrafish circler mutants. Neuron. 20:271-283
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