ZFIN is now using GRCz12tu for Genomic Data
Gene
iqgap3
- ID
- ZDB-GENE-160226-1
- Name
- IQ motif containing GTPase activating protein 3
- Symbol
- iqgap3 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable GTPase activator activity; actin filament binding activity; and calmodulin binding activity. Acts upstream of or within several processes, including auditory behavior; convergent extension involved in gastrulation; and neuromast hair cell development. Predicted to be located in plasma membrane bounded cell projection. Predicted to be active in cell cortex. Is expressed in digestive system; pectoral fin bud; pharyngeal arch; sensory system; and ventricular zone. Used to study nonsyndromic deafness. Orthologous to human IQGAP3 (IQ motif containing GTPase activating protein 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| nonsyndromic deafness | s356tTg + MO2-iqgap3 | control | Li et al., 2025 |
| nonsyndromic deafness | WT + MO2-iqgap3 | control | Li et al., 2025 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR000048 | IQ motif, EF-hand binding site |
| Conserved_site | IPR023152 | Ras GTPase-activating protein, conserved site |
| Domain | IPR000593 | RasGAP protein, C-terminal |
| Domain | IPR001202 | WW domain |
| Domain | IPR001715 | Calponin homology domain |
| Domain | IPR001936 | Ras GTPase-activating domain |
| Homologous_superfamily | IPR008936 | Rho GTPase activation protein |
| Homologous_superfamily | IPR036872 | CH domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Calponin homology domain | CH domain superfamily | IQ motif, EF-hand binding site | RasGAP protein, C-terminal | Ras GTPase-activating domain | Ras GTPase-activating protein, conserved site | Rho GTPase activation protein | WW domain |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0F7EVQ6 | InterPro | 1639 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
iqgap3-201
(1)
|
Ensembl | 4,920 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers