Gene
foxo4
- ID
- ZDB-GENE-150311-1
- Name
- forkhead box O4
- Symbol
- foxo4 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within intracellular oxygen homeostasis and response to hypoxia. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in blastoderm; brain; eye; muscle; and pericardial region. Orthologous to human FOXO4 (forkhead box O4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Shi et al., 2023
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR030456 | Fork head domain conserved site 2 |
| Domain | IPR001766 | Fork head domain |
| Domain | IPR032067 | FOXO protein, transactivation domain |
| Domain | IPR047409 | Forkhead box protein O4, forkhead domain |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Forkhead box protein O4, forkhead domain | Fork head domain | Fork head domain conserved site 2 | FOXO protein, transactivation domain | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:F1R3E6
|
626 |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance