Gene

clpb

ID

ZDB-GENE-150227-1

Name

ClpB family mitochondrial disaggregase

Symbol

clpb Nomenclature History

Previous Names

si:ch1073-119b3.1

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Involved in cerebellum development and thigmotaxis. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria with cataracts, neurologic involvement and neutropenia. Orthologous to human CLPB (caseinolytic mitochondrial matrix peptidase chaperone subunit B).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With clpb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
3-methylglutaconic aciduria type 7a	Alliance	3-methylglutaconic aciduria, type VIIA, autosomal dominant	619835
3-methylglutaconic aciduria type 7b	Alliance	3-methylglutaconic aciduria, type VIIB, autosomal recessive	616271
3-methylglutaconic aciduria with cataracts, neurologic involvement and neutropenia	Alliance	3-methylglutaconic aciduria, type VIIB, autosomal recessive	616271
		Neutropenia, severe congenital, 9, autosomal dominant	619813

Associated With clpb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003593	AAA+ ATPase domain
Domain	IPR003959	ATPase, AAA-type, core
Domain	IPR019489	Clp ATPase, C-terminal
Family	IPR001270	ClpA/B family
Family	IPR050130	ATP-dependent Clp protease/Chaperone ClpA/ClpB
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036770	Ankyrin repeat-containing domain superfamily
Repeat	IPR002110	Ankyrin repeat

Domain Details Per Protein

Protein	Length	AAA+ ATPase domain	Ankyrin repeat	Ankyrin repeat-containing domain superfamily	ATPase, AAA-type, core	ATP-dependent Clp protease/Chaperone ClpA/ClpB	ClpA/B family	Clp ATPase, C-terminal	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A0A8M3AT32 InterPro	655

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	clpb-201 (1) Ensembl	Ensembl		3,033 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations