ZFIN is now using GRCz12tu for Genomic Data
Gene
llcp
- ID
- ZDB-GENE-141219-12
- Name
- lisH-containing low complexity protein
- Symbol
- llcp Nomenclature History
- Previous Names
-
- si:ch73-308l14.2
- tcof1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Human ortholog(s) of this gene implicated in Treacher Collins syndrome and Treacher Collins syndrome 1. Orthologous to human TCOF1 (treacle ribosome biogenesis factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR006594 | LIS1 homology motif |
Domain Details Per Protein
| Protein | Additional Resources | Length | LIS1 homology motif |
|---|---|---|---|
| UniProtKB:E7F9D9 | InterPro | 628 | |
| UniProtKB:A0A8M9QB70 | InterPro | 600 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
si:ch73-308l14.2-201
(1)
|
Ensembl | 2,403 nt | ||
| mRNA |
si:ch73-308l14.2-202
(1)
|
Ensembl | 2,194 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers
- Comparative Orthology
- Alliance
- Gene Tree
- Ensembl
- Note
- Orthology evidence for TCOF1 was removed. From Hill‑Terán et al (2023): NOLC1 and TCOF1 are IDPs, meaning they lack well-defined structural domains and a stable tertiary structure. Algorithms underlying existing MSA software are directly or indirectly based on knowledge obtained from studying 3D protein structures (Lange et al. 2016), and so, these procedures may not be fully reliable when performed on IDPs [to establish orthology].