Gene
mymx
- ID
- ZDB-GENE-141216-172
- Name
- myomixer
- Symbol
- mymx Nomenclature History
- Previous Names
-
- si:ch1073-268j14.1 (2)
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Acts upstream of or within myoblast fusion. Is expressed in myotome and somite.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sw101 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| sw102 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| sw103 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| sw104 | Allele with one insertion | Unknown | Unknown | CRISPR | |
| zf3023 | Allele with one delins | Unknown | Unknown | CRISPR | |
| zf3024 | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-mymx | (3) | |
| CRISPR2-mymx | Shi et al., 2017 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Carey-Fineman-Ziter syndrome 2 | 619941 |
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Domain, Family, and Site Summary
No data available
Domain Details Per Protein
No data available
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
si:ch1073-268j14.1-201
(1)
|
Ensembl | 3,166 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-268J14 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005173026 (1) | 8381 nt | ||
| Genomic | GenBank:CU929120 (2) | 40660 nt | ||
| Polypeptide | RefSeq:XP_005173083 (1) | 2140 aa |
- Luo, Z., Shi, J., Pandey, P., Ruan, Z.R., Sevdali, M., Bu, Y., Lu, Y., Du, S., Chen, E.H. (2022) The cellular architecture and molecular determinants of the zebrafish fusogenic synapse. Developmental Cell. 57(13):1582-1597.e6
- Mendieta-Serrano, M.A., Dhar, S., Ng, B.H., Narayanan, R., Lee, J.J.Y., Ong, H.T., Toh, P.J.Y., Röllin, A., Roy, S., Saunders, T.E. (2022) Slow muscles guide fast myocyte fusion to ensure robust myotome formation despite the high spatiotemporal stochasticity of fusion events. Developmental Cell. 57(17):2095-2110.e5
- Perello-Amoros, M., Rallière, C., Gutiérrez, J., Gabillard, J.C. (2021) Myomixer is expressed during embryonic and post-larval hyperplasia, muscle regeneration and differentiation of myoblats in rainbow trout (Oncorhynchus mykiss). Gene. 790:145688
- Ganassi, M., Badodi, S., Wanders, K., Zammit, P.S., Hughes, S.M. (2020) Myogenin is an essential regulator of adult myofibre growth and muscle stem cell homeostasis. eLIFE. 9:
- Ganassi, M., Badodi, S., Ortuste Quiroga, H.P., Zammit, P.S., Hinits, Y., Hughes, S.M. (2018) Myogenin promotes myocyte fusion to balance fibre number and size. Nature communications. 9:4232
- Shi, J., Bi, P., Pei, J., Li, H., Grishin, N.V., Bassel-Duby, R., Chen, E.H., Olson, E.N. (2017) Requirement of the fusogenic micropeptide myomixer for muscle formation in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 114(45):11950-11955
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