Gene

si:dkey-10b15.8

ID
ZDB-GENE-141212-238
Name
si:dkey-10b15.8
Symbol
si:dkey-10b15.8 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in positive regulation of apoptotic process; programmed cell death; and proteolysis. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 8; Parkinson's disease; and motor neuron disease. Orthologous to human HTRA2 (HtrA serine peptidase 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With si:dkey-10b15.8 Human Ortholog
No data available
Associated With si:dkey-10b15.8 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001478 PDZ domain
Domain IPR041489 PDZ domain 6
Family IPR001940 Peptidase S1C
Homologous_superfamily IPR009003 Peptidase S1, PA clan
Homologous_superfamily IPR036034 PDZ superfamily
1 - 5 of 5
Domain Details Per Protein
Protein Additional Resources Length PDZ domain PDZ domain 6 PDZ superfamily Peptidase S1C Peptidase S1, PA clan
UniProtKB:F1Q918 InterPro 214
UniProtKB:A0A8M9PLU9 InterPro 215
1 - 2 of 2
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA si:dkey-10b15.8-001 (1) Ensembl 1,254 nt
mRNA zgc:174193-204 (1) Ensembl 1,210 nt
1 - 2 of 2
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations