Gene
slc4a3
- ID
- ZDB-GENE-141006-1
- Name
- solute carrier family 4 member 3
- Symbol
- slc4a3 Nomenclature History
- Previous Names
-
- Ae3 (1)
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable monoatomic anion transmembrane transporter activity and solute:inorganic anion antiporter activity. Acts upstream of or within cardiac muscle cell action potential. Predicted to be located in membrane. Is expressed in fin and fin bud. Used to study short QT syndrome. Orthologous to human SLC4A3 (solute carrier family 4 member 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Shmukler et al., 2014
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Thorsen et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Short QT syndrome 7 | 620231 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| short QT syndrome | AB + MO1-slc4a3 | standard conditions | Thorsen et al., 2017 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018241 | Anion exchange, conserved site |
| Domain | IPR011531 | Bicarbonate transporter-like, transmembrane domain |
| Domain | IPR013769 | Band 3 cytoplasmic domain |
| Family | IPR001717 | Anion exchange protein |
| Family | IPR003020 | Bicarbonate transporter, eukaryotic |
| Homologous_superfamily | IPR016152 | Phosphotransferase/anion transporter |
Domain Details Per Protein
| Protein | Length | Anion exchange, conserved site | Anion exchange protein | Band 3 cytoplasmic domain | Bicarbonate transporter, eukaryotic | Bicarbonate transporter-like, transmembrane domain | Phosphotransferase/anion transporter |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0G2KM71
|
739 | ||||||
|
UniProtKB:A0A096X8J7
|
1170 | ||||||
|
UniProtKB:A0A8M6Z7Y3
|
1005 | ||||||
|
UniProtKB:A0A8M9PRV8
|
1015 | ||||||
|
UniProtKB:A0A8M3AWC1
|
1229 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc4a3-201
(1)
|
Ensembl | 3,300 nt |
Interactions and Pathways
No data available
Plasmids
No data available