Gene
mhc1lca
- ID
- ZDB-GENE-140820-4
- Name
- major histocompatibility complex class I LCA
- Symbol
- mhc1lca Nomenclature History
- Previous Names
-
- sb:eu2458
- si:dkey-225f5.5
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to be located in membrane. Human ortholog(s) of this gene implicated in pulmonary tuberculosis. Orthologous to several human genes including CD1A (CD1a molecule); CD1B (CD1b molecule); and CD1C (CD1c molecule).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2005
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu2458 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR003006 | Immunoglobulin/major histocompatibility complex, conserved site |
| Domain | IPR003597 | Immunoglobulin C1-set |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR011161 | MHC class I-like antigen recognition-like |
| Family | IPR050208 | Antigen-presenting and immune regulatory MHC class I-related |
1 - 5 of 9 Show all
Domain Details Per Protein
| Protein | Additional Resources | Length | Antigen-presenting and immune regulatory MHC class I-related | Immunoglobulin C1-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin/major histocompatibility complex, conserved site | MHC classes I/II-like antigen recognition protein | MHC class I-like antigen recognition-like | MHC class I-like antigen recognition-like superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PDN6 | InterPro | 356 | |||||||||
| UniProtKB:A0A0R4IZK4 | InterPro | 350 |
1 - 2 of 2
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
si:dkey-225f5.5-201
(1)
|
Ensembl | 1,663 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-225F5 | ZFIN Curated Data | |
| Encodes | EST | eu2458 | Thisse et al., 2005 |
1 - 2 of 2
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001340377 (1) | 1671 nt | ||
| Genomic | GenBank:BX682558 (1) | 99226 nt | ||
| Polypeptide | UniProtKB:A0A8M9PDN6 (1) | 356 aa |
No data available
- McConnell, S.C., Hernandez, K.M., Andrade, J., de Jong, J.L.O. (2023) Immune gene variation associated with chromosome-scale differences among individual zebrafish genomes. Scientific Reports. 13:77777777
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Dirscherl, H., Yoder, J.A. (2015) A nonclassical MHC class I U lineage locus in zebrafish with a null haplotypic variant. Immunogenetics. 67(9):501-13
- Briolat, V., Jouneau, L., Carvalho, R., Palha, N., Langevin, C., Herbomel, P., Schwartz, O., Spaink, H.P., Levraud, J.P., Boudinot, P. (2014) Contrasted Innate Responses to Two Viruses in Zebrafish: Insights into the Ancestral Repertoire of Vertebrate IFN-Stimulated Genes. Journal of immunology (Baltimore, Md. : 1950). 192:4328-41
- Dirscherl, H., McConnell, S.C., Yoder, J.A., de Jong, J.L. (2014) The MHC class I genes of zebrafish. Developmental and comparative immunology. 46(1):11-23
1 - 5 of 5
Show