nox4

ID

ZDB-GENE-140808-1

Name

NADPH oxidase 4

Symbol

nox4 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable NAD(P)H oxidase H2O2-forming activity and superoxide-generating NADPH oxidase activity. Predicted to be involved in superoxide metabolic process. Predicted to be located in several cellular components, including endoplasmic reticulum membrane; focal adhesion; and perinuclear region of cytoplasm.

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Chan et al., 2024

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nox4 Human Ortholog

No data available

Associated With nox4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR013130	Ferric reductase transmembrane component-like domain
Domain	IPR017927	FAD-binding domain, ferredoxin reductase-type
Family	IPR000778	Cytochrome b245, heavy chain
Homologous_superfamily	IPR017938	Riboflavin synthase-like beta-barrel
Homologous_superfamily	IPR039261	Ferredoxin-NADP reductase (FNR), nucleotide-binding domain

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M2BKR5	InterPro	565
UniProtKB:A0AC58HDW0	InterPro	450
UniProtKB:A0AC58HDW1	InterPro	450
UniProtKB:A0AC58HDW2	InterPro	565
UniProtKB:A0AC58HDX1	InterPro	533